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Evaluation of rapid antigen test for detection of SARS-CoV-2 virus
dc.creator | Mak, Gannon CK | |
dc.creator | Cheng, Peter KC | |
dc.creator | Lau, Stephen SY | |
dc.creator | Wong, Kitty KY | |
dc.creator | Lau, CS | |
dc.creator | Lam, Edman TK | |
dc.creator | Chan, Rickjason CW | |
dc.creator | Tsang, Dominic NC | |
dc.date.accessioned | 2020-07-28T20:37:57Z | |
dc.date.available | 2020-07-28T20:37:57Z | |
dc.date.created | 2020 | |
dc.identifier.issn | 1386-6532 | spa |
dc.identifier.other | https://doi.org/10.1016/j.jcv.2020.104500 | spa |
dc.identifier.uri | http://hdl.handle.net/20.500.12010/11311 | |
dc.description.abstract | Background: The rapid diagnosis of Coronavirus Disease 2019 (COVID-19) patients is essential to reduce the disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests. Objective: To evaluate the performance of the commercially available BIOCREDIT COVID-19 Ag test and compare it with RT-PCR for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Analytical sensitivity for the detection of SARS-CoV-2 virus was determined for the RAD test using viral culture and RT-PCR as reference methods. The RAD test was further evaluated using respiratory samples collected from confirmed COVID-19 patients. The results were compared with RT-PCR test. Results: The detection limits between RAD test, viral culture and RT-PCR varied hugely. RAD was 103 fold less sensitive than viral culture while RAD was 105 fold less sensitive than RT-PCR. The RAD test detected between 11.1 % and 45.7 % of RT-PCR-positive samples from COVID-19 patients. Conclusions: This study demonstrated that the RAD test serves only as adjunct to RT-PCR test because of potential for false-negative results. | spa |
dc.format.extent | 4 páginas | spa |
dc.format.mimetype | image/jepg | spa |
dc.publisher | Journal of Clinical Virology | eng |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
dc.subject | 2019 novel coronavirus | spa |
dc.subject | SARS-CoV-2 | spa |
dc.subject | COVID-19 | spa |
dc.subject | Rapid antigen detection | spa |
dc.subject | RT-PCR | spa |
dc.subject | Viral culture | spa |
dc.title | Evaluation of rapid antigen test for detection of SARS-CoV-2 virus | spa |
dc.type.local | Artículo | spa |
dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
dc.subject.lemb | COVID-19 | spa |
dc.subject.lemb | SARS-CoV-2 | spa |
dc.subject.lemb | Coronavirus | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
dc.identifier.doi | https://doi.org/10.1016/j.jcv.2020.104500 | spa |