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dc.creatorMak, Gannon CK
dc.creatorCheng, Peter KC
dc.creatorLau, Stephen SY
dc.creatorWong, Kitty KY
dc.creatorLau, CS
dc.creatorLam, Edman TK
dc.creatorChan, Rickjason CW
dc.creatorTsang, Dominic NC
dc.date.accessioned2020-07-28T20:37:57Z
dc.date.available2020-07-28T20:37:57Z
dc.date.created2020
dc.identifier.issn1386-6532spa
dc.identifier.otherhttps://doi.org/10.1016/j.jcv.2020.104500spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11311
dc.description.abstractBackground: The rapid diagnosis of Coronavirus Disease 2019 (COVID-19) patients is essential to reduce the disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests. Objective: To evaluate the performance of the commercially available BIOCREDIT COVID-19 Ag test and compare it with RT-PCR for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Analytical sensitivity for the detection of SARS-CoV-2 virus was determined for the RAD test using viral culture and RT-PCR as reference methods. The RAD test was further evaluated using respiratory samples collected from confirmed COVID-19 patients. The results were compared with RT-PCR test. Results: The detection limits between RAD test, viral culture and RT-PCR varied hugely. RAD was 103 fold less sensitive than viral culture while RAD was 105 fold less sensitive than RT-PCR. The RAD test detected between 11.1 % and 45.7 % of RT-PCR-positive samples from COVID-19 patients. Conclusions: This study demonstrated that the RAD test serves only as adjunct to RT-PCR test because of potential for false-negative results.spa
dc.format.extent4 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherJournal of Clinical Virologyeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subject2019 novel coronavirusspa
dc.subjectSARS-CoV-2spa
dc.subjectCOVID-19spa
dc.subjectRapid antigen detectionspa
dc.subjectRT-PCRspa
dc.subjectViral culturespa
dc.titleEvaluation of rapid antigen test for detection of SARS-CoV-2 virusspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.jcv.2020.104500spa


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