Current Updates on the European and WHO Registered Clinical Trials of Coronavirus Disease 2019 (COVID-19)
Verma, Henu Kumar
Verma, Manish Kumar
Kuru, Cansu İlke
Singh, Anand Narayan
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Background Coronavirus disease 2019 (COVID-19) is a major public health concern currently. To date, there are no approved antiviral drugs or vaccines against this transmissible disease. This report sheds light on available information for a better understanding of clinical trials and pharmacotherapy related to COVID-19. Methods MEDLINE, PubMed, EMBASE, Scopus databases, Web of Science, WHO, and EU clinical trial sites were used to perform comparative analysis. Information was collected on the use of therapeutic agents for human therapy in patients with COVID-19 up to May 2020. Results We have extracted data from 60 clinical trials. Amongst these trials, 34 were from the European Union database of clinical trials and 26 from the National Institute of health. The data selection procedure includes active, completion, and recruitment in progress status. Most of the clinical trials are ongoing and hence, there is a lack of precise results for the treatment. Conclusions There is a lack of high-quality clinical evidence. The protocol to be developed requires large randomized clinical trials with a combination of available drugs and prospective therapies. We propose the usage of a large number of cases and different statistical analyses to conduct systematic clinical trials. This could provide comprehensive information about the clinical trial and potential therapeutic progress.
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