Factors associated with the duration of viral shedding in adults with COVID-19 outside of Wuhan, China: a retrospective cohort study
Date
2020Author
Q, Lin
Yang, Yong
Jiang, Dixuan
Tu, Chao
Wan, Lu
Chen, Xiangyu
Li, Zhihong
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Abstract
Objectives: To investigate factors associated with the duration of viral shedding in patients with
COVID-19, outside of Wuhan.
Methods: In this retrospective cohort study, patients with laboratory-confirmed COVID-19 in Changsha,
China were included. Clinical characteristics, laboratory findings,treatment, and outcome were retrieved.
Univariate and multivariate analyses were performed to explore potential factors.
Results: Overall, 147 patients with COVID-19 were included. The median duration of viral shedding (the
number of days from symptoms onset until the successive negative detection of SARS-CoV-2 RNA) was
17 days (interquartile range [IQR], 12–21). Multivariate Logistic regression analysis indicated that
the highesttemperature at admission (odds ratio [OR], 5.200; 95% confidence interval [CI]: 1.190 22.726;
p = 0.028), time from symptom onset to admission (OR, 1.740; 95% CI: 1.296 2.337; p < 0.001) and
hospital length of stay (OR, 1.604; 95% CI: 1.262 2.040; p < 0.001) were risk factors for prolonged
duration of viral shedding.
Conclusions: This study, with a relatively large sample size, focused on the duration of viral shedding and
related factors in patients with COVID-19, outside of Wuhan, China. Potential risk factors were identified
and should be taken into consideration for the strategy of quarantining infected patients.
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