Background and aims An epidemic outbreak of COVID-19 has increased the demand for medical equipment, medical accessories along with daily essentials for the safety of healthcare workers. This study aims to identify the operational challenges faced by retailers in providing efficient services. The study also aimed to propose the roadmap of Industry 4.0 to reduce the impact of COVID-19. Methods A detailed literature review is done on an epidemic outbreak and supply chain using appropriate keywords on SCOPUS, Science Direct, Google Scholar. Some relevant industry reports and blogs are also taken to get insights. Results We have identified twelve significant challenges for the retail sectors that are acting as operational barriers and provided the application of Industry 4.0 technologies to deal with it. Conclusion Industry 4.0 can act as a significant driver for reducing the impact of identified challenges on retailers to fight against the pandemic. There is a need to build trust and transparency for the effective management of healthcare essentials. The supply chain partners and government bodies should act wisely for improving the services during COVID-19 and of similar situations. The proposed roadmap provide future research directions for researchers working in the area of epidemic control, supply chain, and disaster management.