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dc.creatorSun, Chun-Yang
dc.creatorSun, Ya-Lei
dc.creatorLi, Xin-Min
dc.date.accessioned2020-07-27T15:48:23Z
dc.date.available2020-07-27T15:48:23Z
dc.date.created2020
dc.identifier.otherhttps://doi.org/10.1016/j.ajem.2020.06.069spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11171
dc.description.abstractIntroduction: Chinese medicine (CM) has been used to treat Novel Coronavirus 2019 (COVID -19) pneumonia in China. This meta -analysis was conducted to evaluate the clinical efficacy and safety of CM in the treatment of COVID -19 pneumonia. Methods: Randomized controlled trials (RCTs) involving CM in the treatment of COVID -19 pneumonia were identified from Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Chinese National Knowledge Infrastructure, Chinese Biomedical Database, Wanfang Database and VIP Information Database. The methodological quality of trials was evaluated with Cochrane Hanadbook criteria, and the Cochrane Collaboration’s Review Manager 5.3 software was used for meta -analysis. Results: A total of 7 valid studies involving 681 patients were included. The meta -analysis exhibited in comparison to conventional treatment, CM combined with conventional treatment significantly improved clinical efficacy (RR =1.21, 95% CI [1.08,1.36] ), and significantly increased viral nucleic acid negative conversion rate (RR =1.49, 95% CI [1.13,1.97] ). CM also prominently reduced pulmonary inflammation (RR =1.27, 95% CI [1.12,1.44] ), and improved host immune function(WBC, MD=0.92, 95%CI[0.07,1.76]; LYM, MD=0.33, 95%CI[0.08,0.57]; LYM%, MD=2.90, 95%CI[2.09,3.71]; CRP, MD= -12.66, 95%CI[ -24.40, -0.92]) . Meanwhile, CM did not increase the incidence of adverse reactions(RR=1.17, 95%CI [0.39 , 3 .52] ). Conclusion: According to the allocated data, CM has demonstrated clinical efficacy and safety on COVID -19 pneumonia, which need to be confirmed by high quality, multiple -center, large sample randomized controlled trials.spa
dc.format.extent20 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherAmerican Journal of Emergency Medicineeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectChinese Medicinespa
dc.subjectCOVID -19 Pneumoniaspa
dc.subjectMeta -analysisspa
dc.titleThe role of Chinese medicine in COVID-19 pneumonia: A systematic review and meta-analysisspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.ajem.2020.06.069spa


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