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dc.creatorBadgujar, Kirtikumar C.
dc.creatorBadgujar, Vivek C.
dc.creatorBadgujar, Shamkant B.
dc.date.accessioned2020-07-24T16:56:58Z
dc.date.available2020-07-24T16:56:58Z
dc.date.created2020
dc.identifier.otherhttps://doi.org/10.1016/j.dsx.2020.07.022spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11102
dc.description.abstractBackground and aim: The pandemic COVID-19 occurring due to novel emerging coronavirus2019 (SARS-CoV-2) is severely affecting the worldwide public health, culture, economy and human social behaviour. Till date, there is no approved medicine/ treatment to cure COVID-19, whereas, vaccine development efforts are going on high priority. This review aimed to provide an overview of prior art, recent advances, vaccine designing strategies, current scenario, opportunities and challenges related to development of coronavirus vaccine. Method: A literature survey was conducted using Scopus, PubMed and Google Scholar with the search key as: coronavirus vaccine, SARS vaccine, MERS vaccine and COVID-19 vaccine. Articles related to above search query were retrieved, sorted, analyzed and developed into an easy-tounderstand review. Results: The genome phylogenetic analysis suggested that genomic sequence of SARS-CoV-2 is almost 80 % similar to that of SARS-CoV, further both these viruses bind to same host cell receptor ACE-2. Hence it is expected that, previously available literature data about coronavirus vaccine designing may play crucial role in development of rapid vaccine against COVID-19. In view of this, the present review discuss (i) existing information (from 2003 to present) about the type of vaccine, antigen, immunogenic response, animal model, route of administration, adjuvants and current scenario for designing of coronavirus vaccine (ii) potential factors and challenges related to rapid development of COVID-19 vaccine. Conclusion: In conclusion, we suggest possible target sites for designing of vaccine against SARSCoV-2 virus.spa
dc.format.extent60 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherDiabetes & Metabolic Syndrome: Clinical Research & Reviewseng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCoroanvirus disease vaccinespa
dc.subjectCOVID-19 vaccinespa
dc.subjectAntigensspa
dc.subjectAdjuvantsspa
dc.subjectSpike proteinspa
dc.titleVaccine development against coronavirus (2003 to present): An overview, recent advances, current scenario, opportunities and challengesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.dsx.2020.07.022spa


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