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dc.creatorNasir Abdullahi, Idris
dc.creatorUchenna Emeribe, Anthony
dc.creatorAbimbola Ajayi, Onaoluwa
dc.creatorSoji Oderinde, Bamidele
dc.creatorOhinoyi Amadu, Dele
dc.creatorIherue Osuji, Ahaneku
dc.date.accessioned2020-07-24T16:03:39Z
dc.date.available2020-07-24T16:03:39Z
dc.date.created2020
dc.identifier.issn1658-3612spa
dc.identifier.otherhttps://doi.org/10.1016/j.jtumed.2020.06.005spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/11093
dc.description.abstractObjective: Coronavirus disease 2019 (COVID-19) has caused an unprecedented global health emergency. The COVID-19 pandemic has claimed over 350,000 human lives within five months of its emergence, especially in the USA and the European continent. This study analysed the implications of the genetic diversity and mutations in SARS-CoV-2 on its virulence diversity and investigated Q7 how these factors could affect the successful development and application of antiviral chemotherapy, immunotherapy, serodiagnosis, and vaccination. Methods: All the suitable and eligible full text articles published between 31st December 2019 and 31st May 2020 were filtered and extracted from “PubMed”, “Scopus”, “Web of Science”, and “Hinari” and were critically reviewed. We used the Medical Subject Headings (MeSH) terms “COVID-19, “Mutation”, “Genetic diversity”, “SARS-CoV-2”, “Virulence”, “Pathogenicity”, “Evolution” and “SARS-CoV-2 transmission” for this search. Results: Our search showed that SARS-CoV-2 has persistently undergone significant mutations in various parts of its non-structural proteins (NSPs), including NSP2 and NSP3, S protein, and RNA-dependent RNA polymerase (RdRp). In particular, the S protein was found to be the key determinant of evolution, transmission, and virulence of SARS-CoV-2, and could be a potential target for vaccine development. Additionally, RdRp could be a major target in the development of antivirals for the treatment of COVID-19. Conclusion: Given the critical importance of mutations in the pathogenicity of SARS-CoV-2 and in the development of sero-diagnostics, antivirals, and vaccines, this study recommends continuous molecular surveillance of SARS-CoV-2. This approach would potentially prompt identification of new mutants and their impact on ongoing biomedical interventions and COVID-19 control measures.spa
dc.format.extent7 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherJournal of Taibah Universityeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectRNA-dependent RNA polymerasespa
dc.subjectSARS-CoV-2spa
dc.subjectSerodiagnosisspa
dc.subjectVaccinationspa
dc.titleImplications of SARS-CoV-2 genetic diversity and mutations on pathogenicity of the COVID-19 and biomedical interventionsspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.jtumed.2020.06.005spa


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