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SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes

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Date
2020
Author
Graham, N.S.N.
Junghans, C.
Downes, R.
Sendall, C.
Lai, H.
McKirdy, A.
Elliott, P.
Howard, R.
Wingfield, D.
Priestman, M.
Ciechonska, M.
Cameron, L.
Storch, M.
Crone, M.A.
Freemontl, P.S.
Randell, P.
McLaren, R.
Lang, N.
Ladhani, S.
Sanderson, F.
Sharp, D.J.
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Abstract
Objectives: To understand SARS-Co-V-2 infection and transmission in UK nursing homes in order to develop preventive strategies for protecting the frail elderly residents. Methods: An outbreak investigation involving 394 residents and 70 staff, was carried out in 4 nursing homes affected by COVID-19 outbreaks in central London. Two point-prevalence surveys were performed one week apart where residents underwent SARS-CoV-2 testing and had relevant symptoms documented. Asymptomatic staff from three of the four homes were also offered SARS-CoV-2 testing. Results: Overall, 26% (95% CI 22–31) of residents died over the two-month period. All-cause mortality increased by 203% (95% CI 70–336) compared with previous years. Systematic testing identified 40% (95% CI 35–46) of residents as positive for SARS-CoV-2, and of these 43% (95% CI 34–52) were asymptomatic and 18% (95% CI 11–24) had only atypical symptoms; 4% (95% CI −1 to 9) of asymptomatic staff also tested positive. Conclusions: The SARS-CoV-2 outbreak in four UK nursing homes was associated with very high infection and mortality rates. Many residents developed either atypical or had no discernible symptoms. A number of asymptomatic staff members also tested positive, suggesting a role for regular screening of both residents and staff in mitigating future outbreaks.
Palabras clave
Coronavirus; COVID-19; SARS-CoV-2; Nursing home; Care home; Diagnostic testing
URI
http://hdl.handle.net/20.500.12010/11076
Link to resource
https://doi.org/10.1016/j.jinf.2020.05.073
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  • Documentos científicos relacionados a la COVID-19 [2292]
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Carrera 4 # 22-61 Teléfono: (+57 1) 242 7030 - 018000111022 Fax: (+57 1) 561 2107 Bogotá D.C., Colombia

Fundación Universitaria de Bogotá Jorge Tadeo Lozano | Vigilada Mineducación

Institución de educación superior privada, de utilidad común, sin ánimo de lucro y su carácter académico es el de Universidad.

Reconocimiento personería jurídica: Resolución 2613 del 14 de agosto de 1959 Minjusticia.

Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

 

Términos y condiciones | Políticas