Advances in the possible treatment of COVID-19: A review.
Date
2020Author
Chibber, Pankaj
Assim Haq, Syed
Ahmed, Irfan
Iqbal Andrabi, Nusrit
Singh, Gurdarshan
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Abstract
The emergence of the global pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) has put a challenge to identify or derive the therapeutics for its prevention and treatment. Despite the
unprecedented advances in the modern medicinal system, currently, there are no proven effective therapies.
However, rapid research on SARS-CoV-2 epidemiology help unveiling some new targets for potential drug
therapies. Many drugs have been screened, and even their clinical trials are going on at an exceptional pace.
Amongst these RNA-dependent RNA polymerase inhibitors (favipiravir and remdesivir) and steroids especially
dexamethasone showed promising effects. The biological agents like tocilizumab, interferons, and convalescent
plasma prove to be beneficial in viral clearance. Moreover, many immunomodulatory and viral S protein targeting vaccines have their ongoing clinical trials. The establishment of various in vitro and in vivo models for
preclinical studies can additionally help the current research. The volume and the pace of the clinical trials
launched to evaluate the safety and efficacy of various agents against coronavirus disease 2019 (COVID-19)
reflect the need for high-quality evidence for various therapies to be practiced by clinicians. This study aims to
sum up all the current advances in the global medicinal system against the COVID-19.
Palabras clave
Antivirals; COVID-19; Epidemiology; Therapeutics; Treatments; VaccinesLink to resource
https://doi.org/10.1016/j.ejphar.2020.173372Collections
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