COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses
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Date
2020Author
Adnan Shereen, Muhammad
Khan, Suliman
Kazmi, Abeer
Bashir, Nadia
Siddique, Rabeea
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Abstract
The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and
spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses, therefore bats could be the possible primary
reservoir. The intermediate source of origin and transfer to humans is not known, however, the rapid
human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or
vaccine available to be used against COVID-19. However, few broad-spectrum antiviral drugs have been
evaluated against COVID-19 in clinical trials, resulted in clinical recovery. In the current review, we summarize and comparatively analyze the emergence and pathogenicity of COVID-19 infection and previous
human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). We also discuss the approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak.
Palabras clave
Coronaviruses; COVID-19; Origin; Outbreak; SpreadLink to resource
https://doi.org/10.1016/j.jare.2020.03.005Collections
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