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dc.creatorBosteels, Cedric
dc.creatorNeyt, Katrijn
dc.creatorVanheerswynghels, Manon
dc.creatorvan Helden, Mary J.
dc.creatorSichien, Dorine
dc.creatorDebeuf, Nincy
dc.creatorDe Prijck, Sofie
dc.creatorBosteels, Victor
dc.creatorVandamme, Niels
dc.creatorMartens, Liesbet
dc.creatorSaeys, Yvan
dc.creatorLouagie, Els
dc.creatorLesage, Manon
dc.creatorWilliams, David L.
dc.creatorTang, Shiau-Choot
dc.creatorMayer, Johannes U.
dc.creatorRonchese, Franca
dc.creatorScott, Charlotte L.
dc.creatorHammad, Hamida
dc.creatorGuilliams, Martin
dc.creatorLambrecht, Bart N.
dc.date.accessioned2020-07-22T19:46:52Z
dc.date.available2020-07-22T19:46:52Z
dc.date.created2020-06-16
dc.identifier.issn1074-7613spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1074761320301631?dgcid=rss_sd_all#kwrds0010spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10969
dc.format.extent28 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherImmunityeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectdendritic cellspa
dc.subjectmonocytespa
dc.subjecttranscription factorspa
dc.subjectIRF8spa
dc.subjectvirusspa
dc.subjectCD64spa
dc.subjectinf-cDC2spa
dc.subjectinflammationspa
dc.subjecttype 1 interferonspa
dc.subjectFc receptorspa
dc.subjectconvalescent serumspa
dc.titleInflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infectionspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.immuni.2020.04.005spa
dc.description.abstractenglishThe phenotypic and functional dichotomy between IRF8+ type 1 and IRF4+ type 2 conventional dendritic cells (cDC1s and cDC2s, respectively) is well accepted; it is unknown how robust this dichotomy is under inflammatory conditions, when additionally monocyte-derived cells (MCs) become competent antigen-presenting cells (APCs). Using single-cell technologies in models of respiratory viral infection, we found that lung cDC2s acquired expression of the Fc receptor CD64 shared with MCs and of IRF8 shared with cDC1s. These inflammatory cDC2s (inf-cDC2s) were superior in inducing CD4+ T helper (Th) cell polarization while simultaneously presenting antigen to CD8+ T cells. When carefully separated from inf-cDC2s, MCs lacked APC function. Inf-cDC2s matured in response to cell-intrinsic Toll-like receptor and type 1 interferon receptor signaling, upregulated an IRF8-dependent maturation module, and acquired antigens via convalescent serum and Fc receptors. Because hybrid inf-cDC2s are easily confused with monocyte-derived cells, their existence could explain why APC functions have been attributed to MCs.spa


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