• español
    • English
    • português
  • português 
    • español
    • English
    • português
  • Entrar
Ver item 
  •   Página inicial
  • Productos de Investigación - Creación
  • Repositorio Documental COVID-19
  • Documentos científicos relacionados a la COVID-19
  • Ver item
  •   Página inicial
  • Productos de Investigación - Creación
  • Repositorio Documental COVID-19
  • Documentos científicos relacionados a la COVID-19
  • Ver item
JavaScript is disabled for your browser. Some features of this site may not work without it.
JavaScript esta deshabilitado en su navegador. Algunas características de este sitio no podrán funcionar o visualizarse correctamente sin JavaScript.
RecursosRecursos de apoyo¿Cómo publicar?

Navegar

Todo o repositórioComunidades e ColeçõesPor data do documentoAutoresTítulosAssuntosEsta coleçãoPor data do documentoAutoresTítulosAssuntos

Minha conta

EntrarCadastro

Estatística

Ver as estatísticas de usoView Google Analytics Statistics
Estadísticas GTMVer Estadísticas GTM

Innate immunity in COVID-19 patients mediated by NKG2A receptors, and potential treatment using Monalizumab, Cholroquine, and antiviral agents

Thumbnail

Citación

       
Export: <XML METS>
Visualizar/Abrir
Documento Reservado (172.3Kb)
Fin embargo: 
Data
2020-04-21
Autor
Yaqinuddin, Ahmed
Kashir, Junaid
Metadata
Mostrar registro completo
Documentos PDF
Resumo em língua estrangeira
Following the outbreak of a novel coronavirus (SARS-CoV-2), studies suggest that the resultant disease (COVID-19) is more severe in individuals with a weakened immune system. Cytotoxic T-cells (CTLs) and Natural Killer (NK) cells are required to generate an effective immune response against viruses, functional exhaustion of which enables disease progression. Patients with severe COVID-19 present significantly lower lymphocyte, and higher neutrophil, counts in blood. Specifically, CD8+ lymphocytes and NK cells were significantly reduced in cases of severe infection compared to patients with mild infection and healthy individuals. The NK group 2 member A (NKG2A) receptor transduces inhibitory signalling, suppressing NK cytokine secretion and cytotoxicity. Overexpression of NKG2A has been observed on CD8+ and NK cells of COVID-19 infected patients compared to healthy controls, while NKG2A overexpression also functionally exhausts CD8+ cells and NK cells, resulting in a severely compromised innate immune response. Blocking NKG2A on CD8+ cells and NK cells in cancers modulated tumor growth, restoring CD8+ T and NK cell function. A recently proposed mechanism via which SARS-CoV-2 overrides innate immune response of the host is by over-expressing NKG2A on CD+ T and NK cells, culminating in functional exhaustion of the immune response against the viral pathogen. Monalizumab is an inhibiting antibody against NKG2A which can restore the function of CD8 + T and NK cells in cancers, successfully ceasing tumor progression with no significant side effects in Phase 2 clinical trials. We hypothesize that patients with severe COVID-19 have a severely compromised innate immune response and could be treated via the use of Monalizumab, interferon α, chloroquine, and other antiviral agents.
URI
http://hdl.handle.net/20.500.12010/10964
Link para o recurso
https://www.sciencedirect.com/science/article/pii/S0306987720306241?via%3Dihub
Collections
  • Documentos científicos relacionados a la COVID-19 [2292]
Estadísticas Google Analytics
Comments

Respuesta Comentario Repositorio Expeditio

Gracias por tomarse el tiempo para darnos su opinión.


Carrera 4 # 22-61 Teléfono: (+57 1) 242 7030 - 018000111022 Fax: (+57 1) 561 2107 Bogotá D.C., Colombia

Fundación Universitaria de Bogotá Jorge Tadeo Lozano | Vigilada Mineducación

Institución de educación superior privada, de utilidad común, sin ánimo de lucro y su carácter académico es el de Universidad.

Reconocimiento personería jurídica: Resolución 2613 del 14 de agosto de 1959 Minjusticia.

Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

 

Términos y condiciones | Políticas

 

 


Carrera 4 # 22-61 Teléfono: (+57 1) 242 7030 - 018000111022 Fax: (+57 1) 561 2107 Bogotá D.C., Colombia

Fundación Universitaria de Bogotá Jorge Tadeo Lozano | Vigilada Mineducación

Institución de educación superior privada, de utilidad común, sin ánimo de lucro y su carácter académico es el de Universidad.

Reconocimiento personería jurídica: Resolución 2613 del 14 de agosto de 1959 Minjusticia.

Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

 

Términos y condiciones | Políticas