Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’
Date
2020-06-30Author
Lavezzo, Enrico
Franchin, Elisa
Ciavarella, Constanze
Cuomo-Dannenburg, Gina
Barzon, Luisa
Del Vecchio, Claudia
Rossi, Lucia
Manganelli, Riccardo
Loregian, Arianna
Navarin, Nicolò
Abate, Davide
Sciro, Manuela
Merigliano, Stefano
De Canale, Ettore
Vanuzzo, Maria Cristina
Besutti, Valeria
Saluzzo, Francesca
Onelia, Francesco
Pacenti, Monia
Parisi, Saverio
Carretta, Giovanni
Donato, Daniele
Flor, Luciano
Cocchio, Silvia
Masi, Giulia
Sperduti, Alessandro
Cattarino, Lorenzo
Salvador, Renato
Nicoletti, Michele
Caldart, Federico
Castelli, Gioele
Nieddu, Eleonora
Labella, Beatrice
Fava, Ludovico
Drigo, Matteo
Gaythorpe, Katy A. M.
Brazzale, Alessandra R.
Toppo, Stefano
Trevisan, Marta
Baldo, Vincenzo
Donnelly, Christl A.
Ferguson, Neil M.
Dorigatti, Ilaria
Crisanti, Andrea
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Summary in foreign language
On 21 February 2020, a resident of the municipality of Vo’, a small town near Padua (Italy), died of pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection1. This was the first COVID-19 death detected in Italy since the detection of SARS-CoV-2 in the Chinese city of Wuhan, Hubei province2. In response, the regional authorities imposed the lockdown of the whole municipality for 14 days3. We collected information on the demography, clinical presentation, hospitalization, contact network and the presence of SARS-CoV-2 infection in nasopharyngeal swabs for 85.9% and 71.5% of the population of Vo’ at two consecutive time points. From the first survey, which was conducted around the time the town lockdown started, we found a prevalence of infection of 2.6% (95% confidence interval (CI): 2.1–3.3%). From the second survey, which was conducted at the end of the lockdown, we found a prevalence of 1.2% (95% CI: 0.8–1.8%). Notably, 42.5% (95% CI: 31.5–54.6%) of the confirmed SARS-CoV-2 infections detected across the two surveys were asymptomatic (that is, did not have symptoms at the time of swab testing and did not develop symptoms afterwards). The mean serial interval was 7.2 days (95% CI: 5.9–9.6). We found no statistically significant difference in the viral load of symptomatic versus asymptomatic infections (P = 0.62 and 0.74 for E and RdRp genes, respectively, exact Wilcoxon–Mann–Whitney test). This study sheds new light on the frequency of asymptomatic SARS-CoV-2 infection, their infectivity (as measured by the viral load) and provides new insights into its transmission dynamics and the efficacy of the implemented control measures.
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https://www.nature.com/articles/s41586-020-2488-1Collections
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