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Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019
dc.creator | Zhu, Zhe | |
dc.creator | Cai, Ting | |
dc.creator | Fan, Lingyan | |
dc.creator | Lou, Kehong | |
dc.creator | Hua, Xin | |
dc.creator | Huang, Zuoan | |
dc.creator | Gao, Guosheng | |
dc.date.accessioned | 2020-07-21T19:38:57Z | |
dc.date.available | 2020-07-21T19:38:57Z | |
dc.date.created | 2020 | |
dc.identifier.issn | 1201-9712 | spa |
dc.identifier.other | https://doi.org/10.1016/j.ijid.2020.04.041 | spa |
dc.identifier.uri | http://hdl.handle.net/20.500.12010/10888 | |
dc.description.abstract | Objective: To explore the clinical value of immune-inflammatory markers to assess the severity of coronavirus disease 2019 (COVID-19). Methods: 127 consecutive hospitalized patients with confirmed COVID-19 were enrolled in this study, and classified into non-severe and severe groups. Demographics, symptoms, underlying diseases and laboratory data were collected and assessed for predictive value. Results: Of 127 COVID-19 patients, 16 cases (12.60%) were classified into the severe group. High level of interleukin-6 (IL-6), C-reaction protein (CRP) and hypertension were independent risk factors for the severity of COVID-19. The risk model based on IL-6, CRP and hypertension had the highest area under the receiver operator characteristic curve (AUROC). Additionally, the baseline IL-6 was positively correlated with other immune-inflammatory parameters and the dynamic change of IL-6 in the severe cases were parallel to the amelioration of the disease. Conclusion: Our study showed that high level of IL-6, CRP and hypertension were independent risk factors for assessing the severity of COVID-19. The risk model established upon IL-6, CRP and hypertension had the highest predictability in this study. Besides, IL-6 played a pivotal role in the severity of COVID-19 and had a potential value for monitoring the process of severe cases | spa |
dc.format.extent | 8 páginas | spa |
dc.format.mimetype | application/pdf | spa |
dc.publisher | Science Direct | eng |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
dc.subject | COVID-19 | spa |
dc.subject | SARS-CoV-2 | spa |
dc.subject | Immune-inflammatory parameters | spa |
dc.subject | Cytokine storm | spa |
dc.subject | IL-6 | spa |
dc.title | Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019 | spa |
dc.type.local | Artículo | spa |
dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
dc.subject.lemb | COVID-19 | spa |
dc.subject.lemb | SARS-CoV-2 | spa |
dc.subject.lemb | Coronavirus | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
dc.identifier.doi | https://doi.org/10.1016/j.ijid.2020.04.041 | spa |