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dc.creatorLe Bon, S.D.
dc.creatorHoroi, M.
dc.date.accessioned2020-07-21T18:35:23Z
dc.date.available2020-07-21T18:35:23Z
dc.date.created2020-05-23
dc.identifier.issn0306-9877spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0306987720311555?via%3Dihub#ec-research-dataspa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10878
dc.format.extent3 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherMedical Hypotheseseng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectloss of smellspa
dc.subjectcentral nervous system (CNS)spa
dc.subjectrespiratory neurotropic virusesspa
dc.subjectapoptosisspa
dc.subjectneuroinvasionspa
dc.titleIs anosmia the price to pay in an immune-induced scorched-earth policy against COVID-19?spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.mehy.2020.109881spa
dc.description.abstractenglishSince the outbreak of Coronavirus Disease 2019 (COVID-19), loss of smell has increasingly been reported as a frequent clinical sign. Understanding the underlying mechanism and the prognostic value of this symptom will help better manage patients. SARS-CoV-2, as SARS-CoV-1, may likely spread to the central nervous system (CNS) via the olfactory nerve, a known gateway for respiratory neurotropic viruses. We hypothesise that sudden loss of smell due to COVID-19 is the consequence of a protective host defence mechanism involving apoptosis of olfactory receptor neurons. Sacrificing smelling over neuroprotection is a logical strategy, even more so as olfaction is the only sense with the ability to regenerate in adults. Induced apoptosis of olfactory neurons has been shown in mice, successfully preventing neuroinvasion. On the other hand, adult olfactory neurogenesis has been shown to be regulated in part by the immune system, allowing to restore olfactory function. Understanding anosmia as part of a defence mechanism would support the concept of sudden anosmia as being a positive prognostic factor in the short term. Also, it may orient research to investigate the risk of future neurodegenerative disease linked to persisting coronavirus in neurons.spa


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