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dc.creatorMunster, Vincent J.
dc.creatorFeldmann, Friederike
dc.creatorWilliamson, Brandi N.
dc.creatorvan Doremalen, Neeltje
dc.creatorPérez-Pérez, Lizzette
dc.creatorSchulz, Jonathan
dc.creatorMeade-White, Kimberly
dc.creatorOkumura, Atsushi
dc.creatorCallison, Julie
dc.creatorBrumbaugh, Beniah
dc.creatorAvanzato, Victoria A.
dc.creatorRosenke, Rebecca
dc.creatorHanley, Patrick W.
dc.creatorSaturday, Greg
dc.creatorScott, Dana
dc.creatorFischer, Elizabeth R.
dc.creatorde Wit, Emmie
dc.date.accessioned2020-07-21T16:26:13Z
dc.date.available2020-07-21T16:26:13Z
dc.date.created2020-05-12
dc.identifier.issn1476-4687spa
dc.identifier.otherhttps://www.nature.com/articles/s41586-020-2324-7spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10860
dc.format.extent19 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherScience Directeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectEnfermedad respiratoriaspa
dc.titleRespiratory disease in rhesus macaques inoculated with SARS-CoV-2spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.subject.keywordRespiratory diseasespa
dc.identifier.doihttps://doi.org/10.1038/s41586-020-2324-7spa
dc.description.abstractenglishAn outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started in Wuhan (China) in December 20191,2. Following an unprecedented global spread3, the World Health Organization declared COVID-19 a pandemic on 11 March 2020. Although data on COVID-19 in humans are emerging at a steady pace, some aspects of the pathogenesis of SARS-CoV-2 can be studied in detail only in animal models, in which repeated sampling and tissue collection is possible. Here we show that SARS-CoV-2 causes a respiratory disease in rhesus macaques that lasts between 8 and 16 days. Pulmonary infiltrates, which are a hallmark of COVID-19 in humans, were visible in lung radiographs. We detected high viral loads in swabs from the nose and throat of all of the macaques, as well as in bronchoalveolar lavages; in one macaque, we observed prolonged rectal shedding. Taken together, the rhesus macaque recapitulates the moderate disease that has been observed in the majority of human cases of COVID-19. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease, and aid in the development and testing of medical countermeasures.spa


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