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dc.creatorLiao, Mingfeng
dc.creatorLiu, Yang
dc.creatorYuan, Jing
dc.creatorWen, Yanling
dc.creatorXu, Gang
dc.creatorZhao, Juanjuan
dc.creatorCheng, Lin
dc.creatorLi, Jinxiu
dc.creatorWang, Xin
dc.creatorWang, Fuxiang
dc.creatorLiu, Lei
dc.creatorAmit, Ido
dc.creatorZhang, Shuye
dc.creatorZhang, Zheng
dc.date.accessioned2020-07-17T20:38:12Z
dc.date.available2020-07-17T20:38:12Z
dc.date.created2020-05-12
dc.identifier.issn1546-170Xspa
dc.identifier.otherhttps://www.nature.com/articles/s41591-020-0901-9#article-infospa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10808
dc.format.extent15 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherScience Directeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCélulas inmunesspa
dc.titleSingle-cell landscape of bronchoalveolar immune cells in patients with COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.subject.keywordSingle-cell landscapespa
dc.subject.keywordImmune cellsspa
dc.identifier.doihttps://doi.org/10.1038/s41591-020-0901-9spa
dc.description.abstractenglishRespiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.spa


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