Estimation of the reproductive number of novel coronavirus (COVID-19) and the probable outbreak size on the Diamond Princess cruise ship: A data-driven analysis
Fecha
2020Autor
Zhang, Sheng
Yuan Diao, Meng
Yu, Wenbo
Pei, Lei
Lin, Zhaofen
Chen, Dechang
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Resumen
Backgrounds: Up to February 16, 2020, 355 cases have been confirmed as having COVID-19 infection on
the Diamond Princess cruise ship. It is of crucial importance to estimate the reproductive number (R0) of
the novel virus in the early stage of outbreak and make a prediction of daily new cases on the ship.
Method: We fitted the reported serial interval (mean and standard deviation) with a gamma distribution
and applied “earlyR” package in R to estimate the R0 in the early stage of COVID-19 outbreak. We applied
“projections” package in R to simulate the plausible cumulative epidemic trajectories and future daily
incidence by fitting the data of existing daily incidence, a serial interval distribution, and the estimated R0
into a model based on the assumption that daily incidence obeys approximately Poisson distribution
determined by daily infectiousness.
Results: The Maximum-Likelihood (ML) value of R0 was 2.28 for COVID-19 outbreak at the early stage on
the ship. The median with 95% confidence interval (CI) of R0 values was 2.28 (2.06–2.52) estimated by the
bootstrap resampling method. The probable number of new cases for the next ten days would gradually
increase, and the estimated cumulative cases would reach 1514 (1384–1656) at the tenth day in the
future. However, if R0 value was reduced by 25% and 50%, the estimated total number of cumulative cases
would be reduced to 1081 (981–1177) and 758 (697–817), respectively.
Conclusion: The median with 95% CI of R0 of COVID-19 was about 2.28 (2.06–2.52) during the early stage
experienced on the Diamond Princess cruise ship. The future daily incidence and probable outbreak size
is largely dependent on the change of R0. Unless strict infection management and control are taken, our
findings indicate the potential of COVID-19 to cause greater outbreak on the ship.
© 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases
Palabras clave
Coronavirus; Mathematical model; Reproductive number; EpidemiologyEnlace al recurso
https://doi.org/10.1016/j.ijid.2020.02.033Colecciones
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