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A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Date
2020
Author
Zhou, Peng
Yang, Xing-Lou
Wang, Xian-Guang
Hu, Ben
Zhang, Lei
Zhang, Wei
Si, Hao-Rui
Zhu, Yan
L, Bei
Huang, Chao-Lin
Chen, Hui-Dong
Chen, Jing
Luo, Yun
Guo, Hua
Jiang, Ren-Di
Liu, Mei-Qin
Chen, Ying
Shen, Xu-Rui
Wang, Xi
Zheng, Xiao-Shuang
Zhao, Kai
Chen, Quan-Jiao
Deng, Fei
Liu, Lin-Lin
Yan, Bing
Zhan, Fa-Xian
Wang, Yan-Yi
Xiao1, Geng-Fu
Shi, Zheng-Li
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Abstract
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1–4 . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5–7 . Here we report the identifcation and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confrmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from fve patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fuid of a critically ill patient could be neutralized by sera from several patients. Notably, we confrmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.
Palabras clave
SARS-CoV; COVID-19; Pneumonia
URI
http://hdl.handle.net/20.500.12010/10733
Link to resource
https://doi.org/10.1038/s41586-020-2012-7
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  • Documentos científicos relacionados a la COVID-19 [2292]
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Carrera 4 # 22-61 Teléfono: (+57 1) 242 7030 - 018000111022 Fax: (+57 1) 561 2107 Bogotá D.C., Colombia

Fundación Universitaria de Bogotá Jorge Tadeo Lozano | Vigilada Mineducación

Institución de educación superior privada, de utilidad común, sin ánimo de lucro y su carácter académico es el de Universidad.

Reconocimiento personería jurídica: Resolución 2613 del 14 de agosto de 1959 Minjusticia.

Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional.

 

Términos y condiciones | Políticas