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Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

dc.creatorZost, Seth J.
dc.creatorGilchuk, Pavlo
dc.creatorChen, Rita E.
dc.creatorCase, James Brett
dc.creatorReidy, Joseph X.
dc.creatorTrivette, Andrew
dc.creatorNargi, Rachel S.
dc.creatorSutton, Rachel E.
dc.creatorSuryadevara, Naveenchandra
dc.creatorChen, Elaine C.
dc.creatorBinshtein, Elad
dc.creatorShrihari, Swathi
dc.creatorOstrowski, Mario
dc.creatorChu, Helen Y.
dc.creatorDidier, Jonathan E.
dc.creatorMacRenaris, Keith W.
dc.creatorJones, Taylor
dc.creatorDay, Samuel
dc.creatorMyers, Luke
dc.creatorEun-Hyung Lee, F.
dc.creatorNguyen, Doan C.
dc.creatorSanz, Ignacio
dc.creatorMartinez, David R.
dc.creatorRothlauf, Paul W.
dc.creatorBloyet, Louis-Marie
dc.creatorWhelan, Sean P. J.
dc.creatorBaric, Ralph S.
dc.creatorThackray, Larissa B.
dc.creatorDiamond, Michael S.
dc.creatorCarnahan, Robert H.
dc.creatorCrowe, James E.
dc.date.accessioned2020-07-17T14:43:49Z
dc.date.available2020-07-17T14:43:49Z
dc.date.created2020-07-10
dc.identifier.issn1546-170Xspa
dc.identifier.otherhttps://www.nature.com/articles/s41591-020-0998-x#article-infospa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10725
dc.format.extent20 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherScience Directeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.titleRapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike proteinspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1038/s41591-020-0998-xspa
dc.description.abstractenglishAntibodies are a principal determinant of immunity for most RNA viruses and have promise to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 has caused a global pandemic with millions of infections and hundreds of thousands of deaths to date1,2. In response, we used a rapid antibody discovery platform to isolate hundreds of human monoclonal antibodies (mAbs) against the SARS-CoV-2 spike (S) protein. We stratify these mAbs into five major classes on the basis of their reactivity to subdomains of S protein as well as their cross-reactivity to SARS-CoV. Many of these mAbs inhibit infection of authentic SARS-CoV-2 virus, with most neutralizing mAbs recognizing the receptor-binding domain (RBD) of S. This work defines sites of vulnerability on SARS-CoV-2 S and demonstrates the speed and robustness of advanced antibody discovery platforms.spa


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