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Risk factors for death in 1859 subjects with COVID-19
dc.creator | Chen, Lei | |
dc.creator | Yu, Jianming | |
dc.creator | He, Wenjuan | |
dc.creator | Chen, Li | |
dc.creator | Yuan, Guolin | |
dc.creator | Dong, Fang | |
dc.creator | Chen, Wenlan | |
dc.creator | Cao, Yulin | |
dc.creator | Yang, Jingyan | |
dc.creator | Cai, Liling | |
dc.creator | Wu, Di | |
dc.creator | Ran, Qijie | |
dc.creator | Li, Lei | |
dc.creator | Liu, Qiaomei | |
dc.creator | Ren, Wenxiang | |
dc.creator | Gao, Fei | |
dc.creator | Wang, Hongxiang | |
dc.creator | Chen, Zhichao | |
dc.creator | Peter Gale, Robert | |
dc.creator | Li, Qiubai | |
dc.creator | Hu, Yu | |
dc.date.accessioned | 2020-07-17T14:14:32Z | |
dc.date.available | 2020-07-17T14:14:32Z | |
dc.date.created | 2020-06-16 | |
dc.identifier.issn | 1476-5551 (online) | spa |
dc.identifier.other | https://www.nature.com/articles/s41375-020-0911-0 | spa |
dc.identifier.uri | http://hdl.handle.net/20.500.12010/10717 | |
dc.format.extent | 11 páginas | spa |
dc.format.mimetype | application/pdf | spa |
dc.publisher | Leukemia | eng |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
dc.subject | Risk factors for death | spa |
dc.subject | Wuhan | spa |
dc.title | Risk factors for death in 1859 subjects with COVID-19 | spa |
dc.type.local | Artículo | spa |
dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
dc.subject.lemb | COVID-19 | spa |
dc.subject.lemb | SARS-CoV-2 | spa |
dc.subject.lemb | Coronavirus | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
dc.identifier.doi | https://doi.org/10.1038/s41375-020-0911-0 | spa |
dc.description.abstractenglish | We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06 per year increase; P < 0.001); (2) smoking (HR = 1.84 [1.17, 2.92]; P = 0.009); (3) admission temperature per °C increase (HR = 1.32 [1.07, 1.64]; P = 0.009); (4) Log10 neutrophil-to-lymphocyte ratio (NLR; HR = 3.30 [2.10, 5.19]; P < 0.001); (5) platelets per 10 E + 9/L decrease (HR = 0.996 [0.994, 0.998]; P = 0.001); (6) activated partial thromboplastin (aPTT) per second increase (HR = 1.04 [1.02, 1.05]; P < 0.001); (7) Log10 D-dimer per mg/l increase (HR = 3.00 [2.17, 4.16]; P < 0.001); and (8) Log10 serum creatinine per μmol/L increase (HR = 4.55 [2.72, 7.62]; P < 0.001). In piecewise linear regression analyses Log10NLR the interval from ≥0.4 to ≤1.0 was significantly associated with an increased risk of death. Our data identify covariates associated with risk of in hospital death in persons with COVID-19. | spa |