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dc.creatorRodriguez-Morales, Alfonso J.
dc.creatorCardona-Ospina, Jaime A.
dc.creatorGutiérrez-Ocampo, Estefanía
dc.creatorVillamizar-Peña, Rhuvi
dc.creatorHolguin-Rivera, Yeimer
dc.creatorEscalera-Antezana, Juan Pablo
dc.creatorAlvarado-Arnez, Lucia Elena
dc.creatorBonilla-Aldana, D. Katterine
dc.creatorFranco-Paredes, Carlos
dc.creatorHenao-Martinez, Andrés F.
dc.creatorPaniz-Mondolf, Alberto
dc.creatorLagos-Grisales, Guillermo J.
dc.creatorRamírez-Vallejo, Eduardo
dc.creatorSuárez, Jose A.
dc.creatorZambrano, Lysien I.
dc.creatorVillamil-Gómez, Wilmer E.
dc.creatorBalbin-Ramon, Graciela J.
dc.creatorRabaan, Ali A.
dc.creatorHarapan, Harapan
dc.creatorDhama, Kuldeep
dc.creatorNishiura, Hiroshi
dc.creatorKataoka, Hiromitsu
dc.creatorAhmad, Tauseef
dc.creatorSah, Ranjit
dc.date.accessioned2020-07-16T20:40:38Z
dc.date.available2020-07-16T20:40:38Z
dc.date.created2020
dc.identifier.issn1477-8939spa
dc.identifier.otherhttps://doi.org/10.1016/j.tmaid.2020.101623spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10701
dc.description.abstractIntroduction: An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews on COVID-19 have been published to date. Methods: We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate pooled prevalences and 95% confidence intervals (95%CI). Results: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5–92.9%), cough (57.6%, 95%CI 40.8–74.4%) and dyspnea (45.6%, 95%CI 10.9–80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0–30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7–51.8), 6.2% (95%CI 3.1–9.3) with shock. Some 13.9% (95%CI 6.2–21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR). Conclusion: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of > 13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.spa
dc.format.extent13 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherScience Directeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCoronavirus disease 2019spa
dc.subjectSARS-CoV-2spa
dc.subjectClinical featuresspa
dc.subjectLaboratoryspa
dc.subjectOutcomesspa
dc.subjectEpidemicspa
dc.titleClinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysisspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.tmaid.2020.101623spa


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