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dc.creatorTian, Sufang
dc.creatorXiong, Yong
dc.creatorLiu, Huan
dc.creatorNiu, Li
dc.creatorGuo, Jianchun
dc.creatorLiao, Meiyan
dc.creatorXiao, Shu-Yuan
dc.date.accessioned2020-07-16T18:57:10Z
dc.date.available2020-07-16T18:57:10Z
dc.date.created2020-04-14
dc.identifier.issn1530-0285 (online)spa
dc.identifier.otherhttps://www.nature.com/articles/s41379-020-0536-xspa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10689
dc.format.extent8 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherModern Pathologyeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectPathological studyspa
dc.subjectpostmortem core biopsiesspa
dc.subjectpneumoniaspa
dc.subjectlymphocytopeniaspa
dc.titlePathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsiesspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1038/s41379-020-0536-xspa
dc.description.abstractenglishData on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed postmortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia. The patients’ ages ranged from 59 to 81, including three males and one female. Each patient had at least one underlying disease, including immunocompromised status (chronic lymphocytic leukemia and renal transplantation) or other conditions (cirrhosis, hypertension, and diabetes). Time from disease onset to death ranged from 15 to 52 days. All patients had elevated white blood cell counts, with significant rise toward the end, and all had lymphocytopenia except for the patient with leukemia. Histologically, the main findings are in the lungs, including injury to the alveolar epithelial cells, hyaline membrane formation, and hyperplasia of type II pneumocytes, all components of diffuse alveolar damage. Consolidation by fibroblastic proliferation with extracellular matrix and fibrin forming clusters in airspaces is evident. In one patient, the consolidation consists of abundant intra-alveolar neutrophilic infiltration, consistent with superimposed bacterial bronchopneumonia. The liver exhibits mild lobular infiltration by small lymphocytes, and centrilobular sinusoidal dilation. Patchy necrosis is also seen. The heart shows only focal mild fibrosis and mild myocardial hypertrophy, changes likely related to the underlying conditions. In conclusion, the postmortem examinations show advanced diffuse alveolar damage, as well as superimposed bacterial pneumonia in some patients. Changes in the liver and heart are likely secondary or related to the underlyingspa


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