dc.creator | Jiang, Yujie | |
dc.creator | Wei, Xin | |
dc.creator | Guan, Jingjing | |
dc.creator | Qin, Shuang | |
dc.creator | Wang, Zhongyong | |
dc.creator | Lu, Hong | |
dc.creator | Qian, Jingjing | |
dc.creator | Wu, Lianfeng | |
dc.creator | Chen, Yingxiao | |
dc.creator | Chen, Yanfan | |
dc.creator | Lin, Xiangyang | |
dc.date.accessioned | 2020-07-16T16:02:28Z | |
dc.date.available | 2020-07-16T16:02:28Z | |
dc.date.created | 2020 | |
dc.identifier.issn | 1521-6616 | spa |
dc.identifier.other | https://doi.org/10.1016/j.clim.2020.108516 | spa |
dc.identifier.uri | http://hdl.handle.net/20.500.12010/10659 | |
dc.description.abstract | Background: Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim
to investigate the immune status of CD8+ T and NK cells in COVID-19 patients.
Methods: The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals.
Results: As the disease progression in COVID-19 patients, CD8+ T and NK cells were significantly decreased in
absolute number but highly activated. After patients' condition improved, the count and immune status of CD8+
T and NK cells restored to some extent. GrA+CD8+ T and perforin+ NK cells had good sensitivity and specificity
for assisting diagnosis of COVID-19.
Conclusions: As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8+ T and NK cells. GrA+CD8+ T and perforin+ NK cells might be used as meaningful
indicators for assisting diagnosis of COVID-19. | spa |
dc.format.extent | 9 páginas | spa |
dc.format.mimetype | image/jepg | spa |
dc.publisher | Science Direct | eng |
dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
dc.subject | COVID-19 | spa |
dc.subject | CD8+ T cells | spa |
dc.subject | NK cells | spa |
dc.subject | Perforin | spa |
dc.subject | Granzyme | spa |
dc.title | COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential | spa |
dc.type.local | Artículo | spa |
dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
dc.subject.lemb | COVID-19 | spa |
dc.subject.lemb | SARS-CoV-2 | spa |
dc.subject.lemb | Coronavirus | spa |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
dc.identifier.doi | https://doi.org/10.1016/j.clim.2020.108516 | spa |