Show simple item record

dc.creatorJiang, Yujie
dc.creatorWei, Xin
dc.creatorGuan, Jingjing
dc.creatorQin, Shuang
dc.creatorWang, Zhongyong
dc.creatorLu, Hong
dc.creatorQian, Jingjing
dc.creatorWu, Lianfeng
dc.creatorChen, Yingxiao
dc.creatorChen, Yanfan
dc.creatorLin, Xiangyang
dc.date.accessioned2020-07-16T16:02:28Z
dc.date.available2020-07-16T16:02:28Z
dc.date.created2020
dc.identifier.issn1521-6616spa
dc.identifier.otherhttps://doi.org/10.1016/j.clim.2020.108516spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10659
dc.description.abstractBackground: Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8+ T and NK cells in COVID-19 patients. Methods: The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals. Results: As the disease progression in COVID-19 patients, CD8+ T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count and immune status of CD8+ T and NK cells restored to some extent. GrA+CD8+ T and perforin+ NK cells had good sensitivity and specificity for assisting diagnosis of COVID-19. Conclusions: As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8+ T and NK cells. GrA+CD8+ T and perforin+ NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19.spa
dc.format.extent9 páginasspa
dc.format.mimetypeimage/jepgspa
dc.publisherScience Directeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCOVID-19spa
dc.subjectCD8+ T cellsspa
dc.subjectNK cellsspa
dc.subjectPerforinspa
dc.subjectGranzymespa
dc.titleCOVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potentialspa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doihttps://doi.org/10.1016/j.clim.2020.108516spa


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record