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dc.creatorSmith, Trevor R. F.
dc.creatorPatel, Ami
dc.creatorRamos, Stephanie
dc.creatorElwood, Dustin
dc.creatorZhu, Xizhou
dc.creatorYan, Jian
dc.creatorGary, Ebony N.
dc.creatorWalker, Susanne N.
dc.creatorSchultheis, Katherine
dc.creatorPurwar, Mansi
dc.creatorXu, Ziyang
dc.creatorWalters, Jewell
dc.creatorBhojnagarwala, Pratik
dc.creatorYang, Maria
dc.creatorChokkalingam, Neethu
dc.creatorPezzoli, Patrick
dc.creatorReuschel, Emma L.
dc.creatorDoan, Arthur
dc.creatorTursi, Nicholas
dc.creatorVasquez, Miguel
dc.creatorChoi, Jihae
dc.creatorTello-Ruiz, Edgar
dc.creatorMaricic, Igor
dc.creatorBah, Mamadou A.
dc.creatorWu, Yuanhan
dc.creatorAmante, Dinah
dc.creatorPark, Daniel H.
dc.creatorDia, Yaya
dc.creatorAli, Ali Raza
dc.creatorZaidi, Faraz I.
dc.creatorGenerotti, Alison
dc.creatorKim, Kevin Y.
dc.creatorHerring, Timothy A.
dc.creatorReeder, Sophia
dc.creatorAndrade, Viviane M.
dc.creatorButtigieg, Karen
dc.creatorZhao, Gan
dc.creatorWu, Jiun-Ming
dc.creatorLi, Dan
dc.creatorBao, Linlin
dc.creatorLiu, Jiangning
dc.creatorDeng, Wei
dc.creatorQin, Chuan
dc.creatorBrown, Ami Shah
dc.creatorKhoshnejad, Makan
dc.creatorWang, Nianshuang
dc.creatorChu, Jacqueline
dc.creatorWrapp, Daniel
dc.creatorMcLellan, Jason S.
dc.creatorMuthumani, Kar
dc.creatorWang, Bin
dc.creatorCarroll, Miles W.
dc.creatorKim, J. Joseph
dc.creatorBoyer, Jean
dc.creatorKulp, Daniel W.
dc.creatorHumeau, Laurent M. P. F.
dc.creatorWeiner, David B.
dc.creatorBroderick, Kate E.
dc.date.accessioned2020-07-14T00:01:22Z
dc.date.available2020-07-14T00:01:22Z
dc.date.created2020-05-20
dc.identifier.issn2041-1723spa
dc.identifier.otherhttp://www.nature.com/articles/s41467-020-16505-0spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10472
dc.format.extent13 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherScience Directeng
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCoronavirusspa
dc.titleImmunogenicity of a DNA vaccine candidate for COVID-19spa
dc.type.localArtículospa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.identifier.doi10.1038/s41467-020-16505-0spa
dc.description.abstractenglishThe coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, COVID-19. At this time, no vaccine is available to control further dissemination of the disease. We have previously engineered a synthetic DNA vaccine targeting the MERS coronavirus Spike (S) protein, the major surface antigen of coronaviruses, which is currently in clinical study. Here we build on this prior experience to generate a synthetic DNA-based vaccine candidate targeting SARS-CoV-2 S protein. The engineered construct, INO-4800, results in robust expression of the S protein in vitro. Following immunization of mice and guinea pigs with INO-4800 we measure antigen-specific T cell responses, functional antibodies which neutralize the SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and biodistribution of SARS-CoV-2 targeting antibodies to the lungs. This preliminary dataset identifies INO-4800 as a potential COVID-19 vaccine candidate, supporting further translational study.spa


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