Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital
Date
2020-07-08Author
Garcia-Basteiro, Alberto L.
Moncunill, Gemma
Tortajada, Marta
Vidal, Marta
Guinovart, Caterina
Jiménez, Alfons
Santano, Rebeca
Sanz, Sergi
Méndez, Susana
Llupià, Anna
Aguilar, Ruth
Alonso, Selena
Barrios, Diana
Carolis, Carlo
Cisteró, Pau
Chóliz, Eugenia
Cruz, Angeline
Fochs, Silvia
Jairoce, Chenjerai
Hecht, Jochen
Lamoglia, Montserrat
Martínez, Mikel J.
Mitchell, Robert A.
Ortega, Natalia
Pey, Nuria
Puyol, Laura
Ribes, Marta
Rosell, Neus
Sotomayor, Patricia
Torres, Sara
Williams, Sarah
Barroso, Sonia
Vilella, Anna
Muñoz, José
Trilla, Antoni
Varela, Pilar
Mayor, Alfredo
Dobaño, Carlota
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Summary in foreign language
Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1–12.0) were seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2. The cumulative prevalence of SARS-CoV-2 infection (presence of antibodies or past or current positive rRT-PCR) was 11.2% (65/578, 95% CI: 8.8–14.1). Among those with evidence of past or current infection, 40.0% (26/65) had not been previously diagnosed with COVID-19. Here we report a relatively low seroprevalence of antibodies among HCW at the peak of the COVID-19 epidemic in Spain. A large proportion of HCW with past or present infection had not been previously diagnosed with COVID-19, which calls for active periodic rRT-PCR testing in hospital settings.
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https://www.nature.com/articles/s41467-020-17318-xCollections
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