Show simple item record

dc.coverage.spatialColombiaspa
dc.creatorLagier, Jean-Christophe
dc.creatorMillion, Matthieu
dc.creatorGautret, Philippe
dc.creatorColson, Philippe
dc.creatorCortaredona, Sébastien
dc.creatorGiraud-Gatineau, Audrey
dc.creatorHonoré, Stéphane
dc.creatorGaubert, Jean-Yves
dc.creatorFournier, Pierre-Edouard
dc.creatorTissot-Dupont, Hervé
dc.creatorChabrière, Eric
dc.creatorStein, Andreas
dc.creatorDeharo, Jean-Claude
dc.creatorFenollar, Florence
dc.creatorRolain, Jean-Marc
dc.creatorObadia, Yolande
dc.creatorJacquier, Alexis
dc.creatorLa Scola, Bernard
dc.creatorBrouqui, Philippe
dc.creatorDrancourt, Michel
dc.creatorParola, Philippe
dc.creatorRaoult, Didier
dc.date.accessioned2020-07-09T16:41:42Z
dc.date.available2020-07-09T16:41:42Z
dc.date.created2020
dc.identifier.otherhttps://doi.org/10.1016/j.tmaid.2020.101791spa
dc.identifier.urihttp://hdl.handle.net/20.500.12010/10372
dc.description.abstractBackground: In our institute in Marseille, France, we initiated early and massive screening for coronavirus disease 2019 (COVID-19). Hospitalization and early treatment with hydroxychloroquine and azithromycin (HCQ-AZ) was proposed for the positive cases. Methods: We retrospectively report the clinical management of 3,737 screened patients, including 3,119 (83.5%) treated with HCQ-AZ (200 mg of oral HCQ, three times daily for ten days and 500 mg of oral AZ on day 1 followed by 250 mg daily for the next four days, respectively) for at least three days and 618 (16.5%) patients treated with other regimen (“others”). Outcomes were death, transfer to the intensive care unit (ICU), ≥ 10 days of hospitalization and viral shedding. Results: The patients’ mean age was 45 (sd 17) years, 45% were male, and the case fatality rate was 0.9%. We performed 2,065 low-dose computed tomography (CT) scans highlighting lung lesions in 592 of the 991 (59.7%) patients with minimal clinical symptoms (NEWS score = 0). A discrepancy between spontaneous dyspnoea, hypoxemia and lung lesions was observed. Clinical factors (age, comorbidities, NEWS-2 score), biological factors (lymphocytopenia; eosinopenia; decrease in blood zinc; and increase in D-dimers, lactate dehydrogenase, creatinine phosphokinase, and C-reactive protein) and moderate and severe lesions detected in low-dose CT scans were associated with poor clinical outcome. Treatment with HCQ-AZ was associated with a decreased risk of transfer to ICU or death (Hazard ratio (HR) 0.18 0.11- 0.27), decreased risk of hospitalization ≥10 days (odds ratios 95% CI 0.38 0.27-0.54) and shorter duration of viral shedding (time to negative PCR: HR 1.29 1.17-1.42). QTc prolongation (>60 ms) was observed in 25 patients (0.67%) leading to the cessation of treatment in 12 cases including 3 cases with QTc> 500ms. No cases of torsade de pointe or sudden death were observed. Conclusion Although this is a retrospective analysis, results suggest that early diagnosis, early isolation and early treatment of COVID-19 patients, with at least 3 days of HCQ-AZ lead to a significantly better clinical outcome and a faster viral load reduction than other treatments.spa
dc.format.extent39 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.publisherBogotá : Universidad de Bogotá Jorge Tadeo Lozano, 2020spa
dc.subjectSARS-CoV-2spa
dc.subjectCOVID-19spa
dc.subjectHydroxychloroquinespa
dc.subjectAzithromycinspa
dc.titleOutcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysisspa
dc.type.localArtículospa
dc.subject.lembCOVID-19 (Enfermedad) -- Investigacionesspa
dc.subject.lembCOVID-19 (Enfermedad) - Tratamientospa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rights.localAbierto (Texto Completo)spa
dc.identifier.repourlhttp://expeditiorepositorio.utadeo.edu.cospa
dc.identifier.doihttps://doi.org/10.1016/j.tmaid.2020.101791spa
dc.format.rda1 recurso en línea (archivo de texto)spa
dc.type.driverinfo:eu-repo/semantics/articlespa


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record